Biodistribution and safety of a live attenuated tetravalent dengue vaccine in the cynomolgus monkey.

Guillaume Ravel,Nathalie Mantel,Jeremy Silvano,Alexandra Rogue,Bruno Guy,Nicholas Jackson,Nicolas Burdin

Vaccine（2017）

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摘要

•Subcutaneous live, attenuated, tetravalent dengue virus vaccine (CYD-TDV) was well tolerated.•No toxicological findings other than minor local reactions at the injection site.•Transient low level of CYD-TDV RNA detected primarily in blood, the injection site and draining lymph nodes.•Absence of toxicological concern with CYD-TDV.

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关键词

Live attenuated vaccine,Dengue,Cynomolgus monkey,Toxicity,Biodistribution,Shedding

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