How inflammation underlies physical and organ function in acutely admitted older medical patients.

Mechanisms of Ageing and Development(2017)

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摘要
•Inflammation is associated with physical performance and organ dysfunction (FI-OutRef) in acutely admitted older medical patients.•The association between FI-OutRef and physical performance is to some extend mediated by inflammation; mainly related to suPAR.•suPAR and TNFα was unambiguously associated with all physical performance measures and FI-OutRef in unadjusted or adjusted analyses.
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关键词
Biology of Aging,Biomarkers,Inflammation,Accumulated deficiency,Frailty,Acute care settings
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