Improved erythroid differentiation of multiple human pluripotent stem cell lines in microcarrier culture by modulation of Wnt/β-Catenin signaling.

Jaichandran Sivalingam,Hong Yu Chen,Bin-Xia Yang,Zhong Ri Lim,Alan Tin Lun Lam,Tsung Liang Woo,Allen Kuan-Liang Chen,Shaul Reuveny,Yuin-Han Loh,Steve Kah-Weng Oh

HAEMATOLOGICA（2018）

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摘要

Differentiation of O-negative Rhesus factor D negative (O-neg) human induced pluripotent stem cells (hiPSCs) can potentially generate universal donor red blood cells (RBCs) that may be useful for transfusion applications. Among the approaches described for RBCs generation, embryoid body (EB)-

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关键词

Hematopoiesis,O-negative,Red Cells,erythroid differentiation,human iPSC

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