AML refractory to primary induction with Ida-FLAG has a poor clinical outcome

Simon Kavanagh,Emily Heath,Rose Hurren,Marcela Gronda,Samir H. Barghout,Sanduni U. Liyanage,Thirushi P. Siriwardena,Jaime Claudio,Tong Zhang,Mahadeo Sukhai,Tracy L. Stockley,Suzanne Kamel-Reid,Amr Rostom,Andrzej Lutynski,Dina Khalaf, Anna Rydlewski,Steven M. Chan,Vikas Gupta,Dawn Maze,Hassan Sibai

Leukemia Research（2018）

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摘要

•Those refractory to Ida-FLAG induction have a dismal prognosis.•High risk cytogenetics and TP53 mutations are associated with refractoriness.•The dominant genetic mutation persists in patients refractory to Ida-FLAG induction.

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关键词

AML,Chemotherapy,Molecular genetics,Chemosensitivity

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