Systemic inflammation without gliosis mediates cognitive deficits through impaired BDNF expression in bile duct ligation model of hepatic encephalopathy.

Saurabh Dhanda,Smriti Gupta,Avishek Halder,Aditya Sunkaria,Rajat Sandhir

Brain, Behavior, and Immunity（2018）

引用 31|浏览15

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摘要

•Role of inflammation and its influence on cognitive functions has been investigated in HE.•Activation of astrocytes and microglia was not observed in HE.•Systemic inflammation appeared to contribute to cognitive deficits observed in HE.•Reduced expression of BDNF and its upstream transcription factors was observed in HE.

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关键词

AEBSF,ALP,ALT,AST,BBB,BDL,BDNF,BSA,CNS,CREB,DAB-H2O2,EDTA,EGTA,ELISA,FBS,FITC,GAPDH,GFAP,HE,HEPES,HRP,Iba-1,IgG,IL-1β,IL-6,IL-18,MCP-1,MFI,NeuN,NPAS4,PBS,PCR,p-CREB,PE,PVDF,RPMI,SC,SDS-PAGE,SEM,TBS,TNF-α

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