Epigenetic reprogramming enables the transition from primordial germ cell to gonocyte

Peter W. S. Hill,Harry G. Leitch,Cristina E. Requena,Zhiyi Sun,Rachel Amouroux,Monica Roman-Trufero,Malgorzata Borkowska,Jolyon Terragni,Romualdas Vaisvila, Sarah Linnett,Hakan Bagci,Gopuraja Dharmalingham,Vanja Haberle, Boris Lenhard,Yu Zheng,Sriharsa Pradhan,Petra Hajkova

NATURE（2018）

引用 227|浏览71

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摘要

Gonadal germline epigenetic reprogramming involves an interplay between DNA methylation, the polycomb complex and Tet1 in both DNA methylation dependent and independent roles, to ensure the activation of a specific subset of genes critical for progression of gametogenesis.

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关键词

DNA methylation,Epigenomics,Germline development,Reprogramming,Science,Humanities and Social Sciences,multidisciplinary

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