Store-operated Ca2+ entry is not required for fertilization-induced Ca2+ signaling in mouse eggs

Miranda L. Bernhardt,Elizabeth Padilla-Banks,Paula Stein,Yingpei Zhang,Carmen J. Williams

Cell calcium（2017）

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摘要

•SOCE is not required for Ca2+ influx in mouse oocytes and eggs.•Eggs lacking STIM1, STIM2, or ORAI1 have normal Ca2+ oscillations after fertilization.•Oocyte spontaneous Ca2+ influx does not require STIM1, STIM2, or ORAI1.•Trpm7-like channels support Ca2+ influx in mouse oocytes and eggs.

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关键词

Oocyte,Calcium,Store-operated calcium entry,Fertilization,Egg activation

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