Cyclosporin derivatives inhibit hepatitis B virus entry without interfering with NTCP transporter activity.

Satomi Shimura,Koichi Watashi,Kento Fukano,Michael Peel,Ann Sluder,Fumihiro Kawai,Masashi Iwamoto,Senko Tsukuda,Junko S Takeuchi,Takeshi Miyake,Masaya Sugiyama,Yuki Ogasawara,Sam-Yong Park,Yasuhito Tanaka,Hiroyuki Kusuhara,Masashi Mizokami,Camille Sureau,Takaji Wakita

Journal of Hepatology（2017）

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摘要

In this study, we identified new compounds that selectively inhibited hepatitis B virus (HBV) entry, and did not impair bile acid uptake. Our evidence offers a new strategy for developing anti-HBV drugs with fewer side effects.

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关键词

HBV,Infection,NTCP,Membrane transport proteins,Cyclosporine,Antiviral,PreS1,Replication,Hepatitis B virus,Hepatitis D virus,Bile acids and salts,Cyclophilins

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