PIK3CA mutation is associated with increased local failure in lung stereotactic body radiation therapy (SBRT).

Natalie A Lockney,T Jonathan Yang,David Barron,Emily Gelb,Daphna Y Gelblum,Ellen Yorke,Weiji Shi,Zhigang Zhang,Andreas Rimner,Abraham J Wu

Clinical and Translational Radiation Oncology（2017）

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摘要

•An examination of mutations in PIK3CA signaling pathways and radioresistance.•PIK3CA mutation was found to be associated with local failure after lung SBRT.•This is a small study and there is need for further validation.

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关键词

PI3K,PIP2,PIP3,SBRT,AKT,CT,GTV,ITV,CTV,PTV,BED,LF

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