Pharmacological disruption of the MID1/a4 interaction reduces mutant Huntingtin levels in primary neuronal cultures.

Olivia Monteiro,Changwei Chen,Ryan Bingham,Argyrides Argyrou,Rachel Buxton, Christina Pancevac Jönsson,Emma Jones,Angela Bridges,Kelly Gatfield,Sybille Krauß,Jeremy Lambert,Rosamund Langston,Susann Schweiger,Iain Uings

Neuroscience Letters（2018）

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摘要

•Cerebellar granule neurons require nutrient replenishment to maintain expression of HTT in culture.•Peptides derived from α4 disrupt the interaction between MID1 and α4.•Disruption of the MID1 complex by peptides reduces pS6 and HTT expression in CGN cultures.

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关键词

HTT,HD,MID1,PP2A,mHTT,wtHTT,S6K,mTOR,CGN,MAP2,GFAP,aCSF,DIV

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