Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis.

Noemi Eiro,Lucía González,Anxo Martínez-Ordoñez,Belen Fernandez-Garcia,Luis O González,Sandra Cid,Francisco Dominguez,Román Perez-Fernandez,Francisco J Vizoso

Cellular oncology (Dordrecht)（2018）

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摘要

Our data indicate that tumor-derived CAFs can induce up-regulation of genes involved in breast cancer progression. Our data additionally indicate that CAFs, especially those derived from MMP11+ MIC tumors, can promote breast cancer cell invasion and angiogenesis.

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关键词

Cancer-associated fibroblasts,Breast cancer,Tumor invasion,Angiogenesis,MMP11

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