Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia.

Girija Ramakrishnan,Marcia Wright,Masud Alam,Caitlin Naylor,Mamun Kabir,Ayesha Zerin,Tahsin Ferdous,Karl Pedersen,Branwen J Hennig,Jeffrey R Donowitz,Rita Wegmuller,Rashidul Haque,William A Petri,Joel Herbein,Carol A Gilchrist

Diagnostic microbiology and infectious disease（2016）

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摘要

We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1IU/mL.

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