RNA-Binding Protein IGF2BP1 in Cutaneous Squamous Cell Carcinoma.

Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer, accounting for 20% of non-melanoma skin cancer. While most small cSCCs are readily curable by surgical approaches, surgery is not effective for patients with advanced and metastasized cSCC. Prospective study showed that the rate of nodal metastasis and diseasespecific death for cSCC are 4% and 1.5%, respectively (Brantsch et al., 2008). Thus, identification of additional therapeutic targets remains imperative for inoperable SCC.