Quality, immunogenicity and stability of meningococcal serogroup ACWY-CRM, DT and TT glycoconjugate vaccines.

•Mono- and multi-valent MenC conjugate vaccines had similar immunogenicity in mice.•A correlation between size and immune response of MenA conjugates was observed.•Meningococcal serogroup A was the most thermo-labile of MenACWY conjugate vaccines.•Lyophilization of meningococcal group A containing vaccines is advised.