A Marginal Structural Model For Recurrent Events In The Presence Of Time-Dependent Confounding: Non-Specific Effects Of Vaccines On Child Hospitalisations
STATISTICS IN MEDICINE(2016)
摘要
Using a Danish register-based study on childhood vaccination and hospitalisation as motivation, a marginal structural model for recurrent events is studied. The model addresses a number of challenges which may be seen more generally in large register-based cohort studies. One is to adjust for a time-dependent confounder when studying the effect of a time-varying exposure on a recurrent event based on an analysis in continuous time. Another is to report results via a measure which is easy to interpret and communicate even though quite elaborate treatment regimes are considered. Lastly, the implementation of continuously updated weights implies a substantial computationally demanding workload. Copyright (C) 2016 John Wiley & Sons, Ltd.
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关键词
marginal structural model, recurrent events, continuously updated weights, non-specific effects of vaccination, multi-state model
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