Human IgG subtype cross-species reactivity to mouse and cynomolgus monkey Fcγ receptors.

Mehabaw G Derebe,Rupesh K Nanjunda,Gary L Gilliland,Eilyn R Lacy,Mark L Chiu

Immunology Letters（2018）

引用 19|浏览24

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摘要

•Affinities of human, murine and cyno monkey FcγRs against human IgGs is presented.•Cyno FcγRs had higher affinities to human IgGs compared to corresponding human FcγRs.•Cyno FcγRI had nanomolar affinity to human IgG4 PAA while human FcγRI bound weakly.

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关键词

Immunoglobulin G (IgG),Fcγ receptors,Animal models,Cross-species reactivity,Fc-silent IgGs,Surface Plasmon Resonance (SPR)

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