Celastrol pretreatment attenuates rat myocardial ischemia/ reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway.

Suiyang Tong,Liangliang Zhang,Jacob Joseph,Xuejun Jiang

Biochemical and Biophysical Research Communications（2018）

引用 40|浏览4

暂无评分

摘要

These findings suggest that short-term pretreatment with celastrol protects against myocardial I/R injury by suppressing myocardial apoptosis, inflammatory response and oxidative stress via pI3k/Akt pathway activation and HMGB1 inhibition.

查看译文

关键词

Celastrol,Myocardial ischemia/reperfusion injury,Protective effect,PI3K/Akt

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要