Understanding Brain Penetrance of Anticancer Drugs.
NEURO-ONCOLOGY(2018)
摘要
This paper explicates the impact of tumor capillary permeability for glioma World Health Organization (WHO) grades II to IV on brain-penetrant drug entry and distribution within the tumor and the brain adjacent to tumor (leading edge). In addition, we consider the distribution of non-brain penetrant drugs and how, in some cases, large-molecular-weight drugs might achieve good distribution into tumor and brain adjacent to tumor.
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关键词
brain tumor,glioma,neuroimaging,permeability
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