Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines.

Jeroen Declercq,Bruno Ramos-Molina,Ragna Sannerud,Bas Brouwers,Vincent P E G Pruniau,Sandra Meulemans,Evelyn Plets,Wim Annaert,John W M Creemers

European Journal of Cell Biology（2017）

引用 9|浏览29

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摘要

•PC7 internalization requires a cluster of basic amino acids and two palmitoylated cysteines.•PC7 and Furin both recycle to the TGN via late endosomes.•Unlike Furin, PC7 recycles to a sialyltransferase-deficient compartment of the TGN.

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关键词

Proprotein convertase 7,PC7,Trafficking,TGN,Endocytosis

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