Lis1 dysfunction leads to traction force reduction and cytoskeletal disorganization during cell migration

Guo-Wei Jheng
Guo-Wei Jheng
Chia-Ming Chang
Chia-Ming Chang
Chun-Chieh Wu
Chun-Chieh Wu
Jia-Shing Cheng
Jia-Shing Cheng
Hsiao-Hui Lee
Hsiao-Hui Lee
Yang-Kao Wang
Yang-Kao Wang
Juan C Del Álamo
Juan C Del Álamo

Biochemical and biophysical research communications, 2018.

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Keywords:
ActinFocal adhesionLis1MicrotubuleMigrationMore(1+)

Abstract:

Cell migration is a critical process during development, tissue repair, and cancer metastasis. It requires complex processes of cell adhesion, cytoskeletal dynamics, and force generation. Lis1 plays an important role in the migration of neurons, fibroblasts and other cell types, and is essential for normal development of the cerebral cort...More

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