Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation
NATURE IMMUNOLOGY(2017)
摘要
No response by an immune cell occurs in isolation but is instead the summation of multiple interacting signals. Ivashkiv and colleagues describe the epigenetic landscape that results from the integration of the inflammatory cytokines type I interferons and TNF.
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关键词
Immunology,Inflammation,Interferons,Monocytes and macrophages,Tumour-necrosis factors,Biomedicine,general,Infectious Diseases
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