Cardiac and placental mitochondrial characterization in a rabbit model of intrauterine growth restriction.

M Guitart-Mampel,A Gonzalez-Tendero,S Niñerola,C Morén,M Catalán-Garcia,I González-Casacuberta,D L Juárez-Flores,O Ugarteburu,L Matalonga, M V Cascajo,F Tort,A Cortés,E Tobias,J C Milisenda,J M Grau,F Crispi,E Gratacós,G Garrabou,F Cardellach

Biochimica et Biophysica Acta (BBA) - General Subjects（2018）

引用 13|浏览18

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摘要

•IUGR is associated to cardiovascular remodeling potentially leading to cardiac disease in adulthood.•IUGR and cardiovascular remodeling are associated with mitochondrial imbalance.•Nuclear effector Sirtuin3 is increased in response to mitochondrial alterations.•Dietary interventions aimed to modulate Sirtuin3 may regulate obstetric and cardiac complications.

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关键词

Cardiovascular function,Mitochondrial dysfunction,Sirtuin3,Rabbit animal model,Fetal growth,Mitochondrial complex II

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