Effects of Canagliflozin Versus Glimepiride on Adipokines and Inflammatory Biomarkers in Type 2 Diabetes.

W Timothy Garvey,Luc Van Gaal,Lawrence A Leiter,Ujjwala Vijapurkar,James List,Robert Cuddihy,Jimmy Ren,Michael J Davies

Metabolism（2018）

引用 191|浏览14

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摘要

•Canagliflozin reduced HbA1c and provided greater weight loss vs glimepiride.•Canagliflozin decreased serum leptin and increased serum adiponectin vs glimepiride.•Canagliflozin also decreased serum IL-6 and increased TNFα vs glimepiride.•No meaningful changes in biomarkers were seen with glimepiride.•Canagliflozin may improve adipose tissue function and cardiometabolic health.

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关键词

ANCOVA,CANA,CANVAS,CI,CRP,GLIM,HDL-C,IL-6,LDL-C,LS,MCP-1,PAI-1,PPARγ,SD,SE,SGLT2,TNFα,VCAM-1

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