Nasal delivery of Protollin-adjuvanted H5N1 vaccine induces enhanced systemic as well as mucosal immunity in mice.

Weiping Cao,Jin Hyang Kim,Adrian J Reber,Mary Hoelscher,Jessica A Belser,Xiuhua Lu,Jacqueline M Katz,Shivaprakash Gangappa,Martin Plante,David S Burt,Suryaprakash Sambhara

Vaccine（2017）

引用 7|浏览20

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摘要

•Protollin-adjuvanted H5N1 vaccine enhanced serum protective antibody responses and mucosal IgA responses.•Protollin-adjuvanted H5N1 vaccine increased the early B cell response in the lymph nodes and spleen.•Protollin-adjuvanted H5N1 vaccine increased the frequency of Ag-specific antibody secreting cells and T cells.•Protollin-adjuvanted H5N1 vaccine conferred enhanced protection against viral challenge.

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关键词

Protollin,H5N1 vaccines,Mucosal immunity,Cell-mediated immunity,Antibody responses,Protective immunity,Mouse model

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