The cyclophilin-inhibitor alisporivir stimulates antigen presentation thereby promoting antigen-specific CD8(+) T cell activation.

Katharina Esser-Nobis,Julia Schmidt,Katja Nitschke,Christoph Neumann-Haefelin,Robert Thimme,Volker Lohmann

Journal of Hepatology（2016）

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摘要

Alisporivir stimulates antigen presentation by inducing enhanced MHC-I surface expression, thereby promoting antigen-specific CD8(+) T cell activation. This immunostimulatory function might further contribute to the antiviral activity of non-immunosuppressive cyclophilin-inhibitors.

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关键词

HCV,CsA,MHC,Cyp,E:T ratio,NS5BEM,IFN,b2m,GLuc,TFR,ERAP1,SFA,CsH,TCR,GeoMFI

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