Sweet Vector for Gene Delivery: the Sugar Decoration of Polyplexes Reduces Cytotoxicity with a Balanced Effect on Gene Expression

    Lindomar J C Albuquerque
    Lindomar J C Albuquerque
    Alex C Alavarse
    Alex C Alavarse
    Morgana S Zilse
    Morgana S Zilse
    Maitê T Barth
    Maitê T Barth

    Macromolecular bioscience, Volume 18, Issue 2, 2018.

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    Keywords:
    gene deliverylactosesugar functionalizationsweet polyplexes

    Abstract:

    The use of sugar-functionalized polyplexes as a nonviral gene delivery vector with lower cytotoxicity than the well-known polymeric carrier branched polyethyleneimine (BPEI) is investigated. The substitution of primary amine groups in the BPEI chains with lactose residues leads to larger polyplexes, presumably due to the higher amount of ...More

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