Terpenoids from Vitex trifolia and their anti-inflammatory activities

A new diterpenoid glucoside, (3 S ,5 S ,6 S ,8 R ,9 R ,10 S )-3,6,9-trihydroxy-13(14)-labdean-16,15-olide 3- O - β -D-glucopyranoside ( 1 ), and a new iridoid glucoside, (1 S , 5 S ,6 R ,9 R )-10- O - p -hydroxybenzoyl-5,6 β -dihydroxy iridoid 1- O - β -D-glucopyranoside ( 2 ), along with six known compounds ( 3-8 ) were isolated from Vitex trifolia L.. Their structures were elucidated by extensive spectroscopic analysis. All these isolated compounds were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 macrophages. Compounds 2 , 4 , 5 , and 7 showed moderate inhibitory activities with IC 50 values of 90.05, 88.51, 87.26, and 76.06 μ M, respectively.