Liver fibrosis marker, 7S domain of collagen type IV, in patients with pre-capillary pulmonary hypertension.

Akiomi Yoshihisa,Yusuke Kimishima,Takatoyo Kiko,Yu Sato,Shunsuke Watanabe,Yuki Kanno,Satoshi Abe,Makiko Miyata-Tatsumi,Takamasa Sato,Satoshi Suzuki,Masayoshi Oikawa,Atsushi Kobayashi,Takayoshi Yamaki,Koichi Sugimoto,Hiroyuki Kunii,Kazuhiko Nakazato,Hitoshi Suzuki,Takafumi Ishida,Yasuchika Takeishi

International Journal of Cardiology（2018）

引用 20|浏览11

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摘要

•Pulmonary hypertension (PH) causes right ventricular dysfunction, and may lead to congestive hepatopathy.•The serum 7S domain of collagen type IV (P4NP 7S) is an established marker of liver fibrosis in chronic liver disease.•In the present study, P4NP 7S correlates with central venous pressure and right-sided volume overload in PH patients.•Serum P4NP 7S is comparable or superior to other known biomarkers regarding predicting mortality in PH patients.

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关键词

Pulmonary hypertension,Liver fibrosis,Serum 7S domain of collagen type IV,Hemodynamics,Mortality

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