Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway.

Jingren Xu,Canjun Zhu,Mengyuan Zhang,Qingchun Tong,Xiaojuan Wan,Zhengrui Liao,Xingcai Cai,Yaqiong Xu,Yexian Yuan,Lina Wang,Xiaotong Zhu,Songbo Wang,Ping Gao,Qianyun Xi,Yong Xu,Qingyan Jiang,Gang Shu

Metabolism（2018）

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摘要

Our results demonstrate a previously unappreciated pathway involving Arg that reverses GH resistance and alleviates malnutrition-induced growth restriction through the inhibition of TLR4-mediated inflammatory pathway.

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关键词

Ala,Arg,CR,GH,GHR,GHRH,IGF-1,IL,IKKα/β,JAK2,LPS,mTOR,PTP1B,SOCS3,STAT5,SST,TNFα,TLR

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