Biphasic activation of complement and fibrinolysis during the human nasal allergic response.

Ryan S Thwaites,Natasha C Gunawardana, Verena Broich,Elizabeth H Mann,Josefin Ahnström,Gaynor A Campbell,Sarah Lindsley,Nehmat Singh,Tanushree Tunstall,David A Lane,Peter J Openshaw,Catherine M Hawrylowicz,Trevor T Hansel

Journal of Allergy and Clinical Immunology（2018）

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摘要

Complement, coagulation and fibrinolysis contribute to the pathology of many respiratory diseases. Here we detail the biphasic activation of these pathways following nasal allergen challenge. Understanding these mechanisms may lead to therapeutic insight in common respiratory diseases.

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