Evidence-based and consensus clinical practice guidelines for the iron treatment of restless legs syndrome/Willis-Ekbom disease in adults and children: an IRLSSG task force report.

•Iron treatments should be considered for all RLS patients.•Morning, fasting serum iron, ferritin, TIBC and %TSAT should be obtained.•No iron treatment should be used if %TSAT >45.•Oral iron treatment if tolerated and safe should be considered for ferritin ≤75 μg/l.•Consider IV iron when oral iron is not appropriate provided ferritin ≤100 μg/l.