Taste masking and rheology improvement of drug complexed with beta-cyclodextrin and hydroxypropyl-β-cyclodextrin by hot-melt extrusion.

Lorena F B Malaquias,Lívia C L Sá-Barreto,Daniel O Freire,Izabel C R Silva,Kapish Karan,Thomas Durig,Eliana M Lima,Ricardo N Marreto,Guilherme M Gelfuso,Tais Gratieri,Marcilio Cunha-Filho

Carbohydrate Polymers（2018）

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摘要

•Fluconazole-cyclodextrin inclusion complex were produced using hot melt extrusion.•Inclusion complexes were obtained with high complexation efficiency.•Improvements on drug rheology, palatability and dissolution rate were achieved.

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关键词

Cyclodextrin,Hot-melt extrusion,Rheology,Palatability,E-tongue,Antifungal assay

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