Predicting mutant selection in competition experiments with ciprofloxacin-exposed Escherichia coli.

David D Khan,Pernilla Lagerbäck,Christer Malmberg,Anders N Kristoffersson,Erik Wistrand-Yuen,Cao Sha,Otto Cars,Dan I Andersson,Diarmaid Hughes,Elisabet I Nielsen,Lena E Friberg

International Journal of Antimicrobial Agents（2018）

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摘要

•A previously developed PK/PD model was challenged to predict time–kill competition experiments.•Selection of wild-type versus mutant strains was reasonably well forecast.•PK/PD models can be of value in exploring the impact of exposure on resistance selection.

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关键词

Pharmacokinetics/Pharmacodynamics,PK/PD modelling,PK/PD predictions,Ciprofloxacin,Escherichia coli,Time–kill experiments

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