Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study.

Rajanikanta Sahu, Tausif Ahmed,Ramchandra Sangana, Ravindra Punde,Bharat Bhusan Subudhi

Journal of Pharmaceutical and Biomedical Analysis（2018）

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摘要

•Tinospora Cordifolia extract significantly inhibited Cytochrome P450 isoenzymes.•Metabolism of Glibenclamide was inhibited with increasing concentration of extract.•Following co-administration, increased Glibenclamide bioavailability was observed.

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关键词

TC,TCE,CYP,CAM,IS,LLOQ-QC,LQC,MQC,HQC,IVC,USFDA,CPCSEA,LC–HRMS,HLM,RLM,IC50

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