High-dose hypofractionated radiotherapy is effective and safe for tumors in the head-and-neck.

•Hypofractionated head and neck radiation therapy is controversial due to toxicity concerns.•62 sites of measurable head-and-neck tumors were treated with high-dose radiation therapy.•Dose per fraction of 6Gy or greater had improved locoregional control.•Re-irradiated patients had worse disease control after hypofractionated radiation.•No increased toxicity was seen in patients treated with higher doses per fraction.