To Die Or Not To Die: Regulatory Feedback Phosphorylation Circuits Determine Receptor-Interacting Protein Kinase-1 (Ripk1) Function

Complex posttranslational modifications determine the effects of receptor-interacting protein kinase-1 RIPK1) on cell survival and death. Studies from us and others have revealed a p38(MAPK)/MK2-dependent checkpoint in RIPK1 signaling. MAPKAP kinase 2 (MK2) phosphorylates RIPK1 to suppress RIPK1 mediated apoptosis and necroptosis in response to diverse stimuli relevant to inflammation, infection, genotoxic stress and chemotherapy.