Radiotherapy Upregulates Programmed Death Ligand-1 through the Pathways Downstream of Epidermal Growth Factor Receptor in Glioma.

•The PD-L1 expression was significantly correlated with EGFR expression in glioma specimens.•RT promoted the phosphorylation of EGFR to activate the JAK2 pathway, which resulted in the upregulation of PD-L1.•Inhibition of EGFR pathway could abrogate the RT-triggered PD-L1 up-regulation.