Efficacy of repeated low-dose bevacizumab treatment with long-dosing interval for radiation-induced brain necrosis: A case report.

A 40-year-old Chinese female patient, with radiation-induced brain necrosis after radiosurgery, was treated 6times with a single dose of 200mg (3.27mg/kg) bevacizumab each time, and with an interval of 12-16weeks between each treatment. Neurological symptoms such as dizziness, fatigue, and headache disappeared after each administration of bevacizumab. The results suggest that repeated bevacizumab treatment using a low-dose and long-dosing interval may significantly alleviate radiation necrosis and its symptoms.