A fluorescent peptidyl substrate for visualizing peptidyl-prolyl cis/trans isomerase activity in live cells.

Quan Jiang,Xiao-Rong Li,Cheng-Kun Wang,Juan Cheng,Chao Tan,Tian-Tian Cui,Nan-Nan Lu,Tony D James,Feng Han,Xin Li

CHEMICAL COMMUNICATIONS（2018）

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摘要

This communication reports on a fluorescent probe (PPI-P) for imaging active peptidyl-prolyl cis/trans isomerases in live cells. PPI-P is capable of responding to both recombinant and cellular PPIases fluorogenically, and has been shown to specifically image active PPIases in live cells.

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