Integrated microreactor for enzymatic reaction automation: An easy step toward the quality control of monoclonal antibodies.

Yoann Ladner,Silvia Mas,Gaelle Coussot, Killian Bartley,Jérôme Montels,Jacques Morel,Catherine Perrin

Journal of Chromatography A（2017）

引用 18|浏览8

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摘要

•Optimization of a nano-enzymatic reactor for in-line digestion of monoclonal antibodies.•Optimization of electrophoretic separation of monoclonal antibody digests.•Comparison of off-line and in-line mAbs digest profiles.

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关键词

Capillary electrophoresis,Monoclonal antibody,Quality control,Enzymatic microreactor,In-line digestion,Proteolysis product separation

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