Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma.

Aswini R Krishnan,Avinaash Korrapati,Angela E Zou,Yuanhao Qu,Xiao Qi Wang,Joseph A Califano,Jessica Wang-Rodriguez,Scott M Lippman,Melbourne F Hovell,Weg M Ongkeko

Oral Oncology（2017）

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摘要

•RNA-seq analysis implicated a 13-member piRNA panel in smoking-related HNSCC.•5 piRNAs correlated with clinical variables, including tumor stage and survival.•mRNA expression analysis revealed dysregulation of PIWIL1 in smoking-related HNSCC.•6 piRNAs as well as PIWIL1 associated with common genomic alterations in HNSCC.

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关键词

Smoking,Head and neck neoplasms,RNA,Small interfering

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