Association analysis of norepinephrine transporter polymorphisms and methylphenidate response in ADHD patients.

Nora Angyal,Erzsebet Zsofia Horvath,Zsanett Tarnok,Mara J Richman,Emese Bognar,Krisztina Lakatos,Maria Sasvari-Szekely,Zsofia Nemoda

Progress in Neuro-Psychopharmacology and Biological Psychiatry（2018）

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摘要

•Case-control analysis of NET polymorphisms in childhood ADHD yielded negative results.•Meta analyses confirmed lack of association between the NET gene and ADHD.•NET rs3785143 SNP showed association with inattention symptoms among ADHD patients.•Haplotype analyses of NET gene intron-1 and promoter SNPs supported this association.•ADHD children with NET rs28386840 T-allele showed better methylphenidate response.

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关键词

ADHD (attention deficit hyperactivity disorder),Methylphenidate,Pharmacogenetics,Norepinephrine/noradrenaline transporter, SLC6A2 (solute carrier family 6, member 2),Promoter polymorphism

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