CDC42-related genes are upregulated in helper T cells from obese asthmatic children.

Deepa Rastogi,John Nico,Andrew D Johnston, Toni Adrianne M Tobias,Yurydia Jorge,Fernando Macian,John M Greally

Journal of Allergy and Clinical Immunology（2018）

引用 29|浏览9

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摘要

Our study identifies the CDC42 pathway as a novel target that is upregulated in T cells of obese asthmatic children, suggesting its role in nonatopic T1-polarized systemic inflammation and pulmonary function deficits found in patients with pediatric obesity-related asthma.

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关键词

Asthma,obesity,helper T cell transcriptome,children

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