Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver.

Debora Nigro, Francesca Menotti,Alessia S Cento,Loredana Serpe,Fausto Chiazza,Federica Dal Bello,Francesco Romaniello,Claudio Medana,Massimo Collino,Manuela Aragno,Raffaella Mastrocola

The Journal of Nutritional Biochemistry（2017）

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摘要

The overconsumption of both saturated fats and fructose in the modern society has been related to the development of nonalcoholic fatty liver disease (NAFLD). However, the specific contribution of individual dietary components on the progression of NAFLD to nonalcoholic steatohepatitis (NASH) has been poorly investigated.

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关键词

ACC,ApoB,COX-1,CPT1-l,FAS,GAPDH,GCLC,GCLM,Gsta,HMG-CoA-R,ICAM-1,IL-1β,Keap1,MPO,NFκB,Nlrp3,Nrf2,Nqo1,SCAP,SDH-A,SREBP1,SREBP2

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