Synthesis of novel chlorhexidine spheres with controlled release from a UDMA-HEMA resin using ultrasound.

•Primary study on synthesis of novel spherical chlorhexidine spheres incorporated in a dental resin.•Novel chlorhexidine spheres incorporated in a dental resin demonstrated lower and responsive chlorhexidine release.•Ultrasonics gave a responsive controlled chlorhexidine release, which is useful to treat severe or persistent infections.•Chlorhexidine spheres produced by co-precipitation may be useful for the treatment of Periodontitis and Peri-implantitis.