Teratogenic and anticonvulsant effects of zinc and copper valproate complexes in zebrafish.

Lauren D Grünspan,Ben Hur M Mussulini,Suelen Baggio,Paulo R Dos Santos,Françoise Dumas,Eduardo P Rico,Diogo L de Oliveira,Sidnei Moura

Epilepsy research（2018）

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摘要

•Valproate organometallic complex increases antiseizure activity.•Cu(Valp)2Bipy produces an antiseizure effect with high toxicity.•Zn(Valp)2Bipy should be the most promising modification for future studies.

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关键词

Zn+2,Cu+2,HPF,FET,Cu(Valp)2Phen,Cu(Valp)2Bipy,Zn(Valp)2Phen,Zn(Valp)2Bipy,VPA,Phen,Bipy,PTZ,LD50,AED,GABA

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