An LC-MS/MS method for quantification of AC0010, a novel mutant-selective epidermal growth factor receptor (EGFR) inhibitor, and its metabolites in human plasma and the application to a pharmacokinetic study.
Journal of Pharmaceutical and Biomedical Analysis(2017)
摘要
•We developed a method for determining a third generation EGFR-TKI AC0010 and six of its metabolites.•We validated the method and applied it to a pharmacokinetic study.•We obtained the PK parameters of AC0010 and its metabolites in patients with NSCLC.
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关键词
DMSO,EGFR-TKI,NSCLC,SPE
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