Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A 2A receptor agonists.

Andrew J Kwilasz,Amanda Ellis,Julie Wieseler,Lisa Loram,Jacob Favret,Andrew McFadden,Kendra Springer,Scott Falci,Jayson Rieger,Steven F Maier,Linda R Watkins

Brain, Behavior, and Immunity（2018）

引用 26|浏览15

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摘要

•Adenosine A2A receptor (A2AR) agonists reverse spinal cord injury (SCI) allodynia.•Anti-IL-10 abolishes A2AR agonist reversal of SCI allodynia.•A2AR agonists decrease mRNA for microglial reactivity and inflammatory markers.

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关键词

ATL313,CGS21680,Mechanical allodynia,Rats,Avulsion,Spinal cord injury

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