Maternal cholesterol influence atherosclerosis progression and reverse cholesterol transport in ApoE?/? offspring in sex-dependent manner.

Aim: Atherosclerosis is a common cause of death and disability throughout the world. The ‘fetal origin’ hypothesis proposes that cardiovascular disease in adult life, originate through the fetus environment (Barker, 1997). Our objective is to check whether the cholesterolemia during gestation affect the development of atherosclerosis kinetic and cholesterol metabolism in ApoE-/- offspring.