Recombinant LCAT restores HDL function in acute coronary syndrome.

Aim: Lecithin:cholesterol acyltransferase (LCAT) is the enzyme responsible for cholesterol esterification in plasma, and plays a key role in HDL remodeling. Few studies have suggested that LCAT activity is decreased in patients with an acute myocardial infarction, but the possible link with the reduced functionality of HDL observed during acute coronary syndrome (ACS) has never been tested. Aim of this study was to evaluate changes in LCAT concentration and activity during STEMI and to investigate if these changes are related to HDL compromised capacity to promote endothelial nitric oxide (NO) production.